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1292 hits

  • Thumbnail for Colorado Mountain Scenery 10
  • Thumbnail for Colorado Mountain Scenery 11 Pikes Peak Highway
  • Thumbnail for Colorado Mountain Scenery 02 Seven Falls
  • Thumbnail for Colorado Mountain Scenery 16 Mt. Massive
  • Thumbnail for Colorado Mountain Scenery 15 Mt. Evans
  • Thumbnail for Letter Seal
    Letter Seal by Unknown

    2 (L) x 1/2 (Dia.) inches. Conical iron seal with leaf-shaped top and scored design, the base with calligraphy.

  • Thumbnail for Chinese Bronze Belt Hook (side two)
    Chinese Bronze Belt Hook (side two)

    3" l. Cast with long scrolled horns flanking a crest, large ears, prominent snout and protruding curved tongue forming the hook.

  • Thumbnail for Chinese Bronze Belt Hook (back)
    Chinese Bronze Belt Hook (back)

    3" l. Oval medallion form cast in relief a striding lion bordered by a rope twist band, terminating in a dragon's head hook.

  • Thumbnail for Carved Gourd with Literary Scenes (1 view 1)
    Carved Gourd with Literary Scenes (1 view 1)

    1 1/2"h x 1 3/4"l (including base). Side view of finely carved gourd showing scenes from literature and opera.

  • Thumbnail for Capsule
    Capsule

    The Capsule sculpture was hung in the atrium of the Colorado College Charles L. Tutt Library in 2014. The medium of the sculpture is welded steel, basketry reeds, and Japanese kozo fiber. The following statement about the piece is by the artist, Erin O'Neill: I was exposed to the art of papermaking in 2013. Immediately taken with this art form, I began experimenting with different ways to make my own paper. Eventually I found a local paper artist, Daria Wilber, who generously showed me the ropes of this medium. Using a Hollander, I beat the bark of Japanese kozo plants into pulp that makes up the underbelly my sculpture. Although this paper is very thin, once it dries it is exceptionally durable. Throughout the past few years of my artistic exploration, I have repeatedly returned to this cocoon-like form. I spent the summer of 2013 working with the CC Grounds Crew, and during this time my awareness of the natural world amplified. I am convinced that it was this work experience in particular that lent itself to my pod-like form. I aspire to live life the same way I observe plants, to soak up the fine details and to heighten the value of my experiences that are often passed off as insignificant or are undervalued.

  • Thumbnail for The Role of ISG15 during Listeria monocytogenes infection
    The Role of ISG15 during Listeria monocytogenes infection by Foecke, Mariko Hinton

    Listeria monocytogenes is a Gram-positive facultative anaerobic bacterium that is the etiological agent of listeriosis, a food-borne illness. In healthy individuals, listeriosis results in mild symptoms, but can be life-threatening for immunocompromised individuals such as the elderly or pregnant women in which case listeriosis can even lead to abortion. During infection with intracellular pathogens like L. monocytogenes, host cells upregulate a plethora of genes involved in combatting the infection. In infection with L. monocytogenes, one such gene is interferon stimulated gene 15 (ISG15), a ubiquitin-like protein, which has been shown to have antiviral activity. Previous work from our group demonstrated, through its effect on cytokines, that ISG15 is also antibacterial. However, we wanted to understand more about the protein’s specific targets. Our group previously identified proteins targeted by ISG15 during L. monocytogenes infection using a combination of proteomic strategies. To confirm the modifications by ISG15 during L. monocytogenes infection, we infected mouse embryonic fibroblasts (MEFs) isolated from deconjugase (USP18) inactive mice, ISG15 knock-out mice, and wild type mice. Using infected cells, we found that ISG15 has a protective effect against L. monocytogenes infection in vitro. Additionally, since previous work has shown that approximately 80% of ISGylation targets are integral membrane proteins localized to the endoplasmic reticulum (ER), we focused specifically on morphological changes to the ER caused by ISG15 induction upon L. monocytogenes infection. Our data suggest that the absence of ISG15 may compromise both nuclear integrity and endoplasmic reticulum morphology. Although the role ISG15 plays upon infection with intracellular bacteria remains elusive, a better understanding of the mechanism of action of the small protein and its role during L. monocytogenes infection could lead to breakthroughs in the study of several human diseases due to the multitude of pathways in which ISG15 has been implicated.

  • Thumbnail for Chinese Bronze Belt Hook (front)
    Chinese Bronze Belt Hook (front)

    3" l. Oval medallion form cast in relief a striding lion bordered by a rope twist band, terminating in a dragon's head hook.

  • Thumbnail for Chinese Bronze Belt Hook (back)
    Chinese Bronze Belt Hook (back)

    3" l. Cast with long scrolled horns flanking a crest, large ears, prominent snout and protruding curved tongue forming the hook.

  • Thumbnail for Chinese Mutton Fat Jade with Wooden Stand - bottom view
    Chinese Mutton Fat Jade with Wooden Stand - bottom view

    3 7/8" l. Greenish-white jade with russet markings carved in an archaistic style standing dragon, handcarved fitted wood stand.

  • Thumbnail for Chinese Bronze Belt Hook (side one)
    Chinese Bronze Belt Hook (side one)

    3" l. Cast with long scrolled horns flanking a crest, large ears, prominent snout and protruding curved tongue forming the hook.

  • Thumbnail for Chinese Enamel Bronze Fingernail Guard (front)
    Chinese Enamel Bronze Fingernail Guard (front)

    3 3/4" l. Arced and tapered fprm with reticulated design on the reverse and enamel floral design on the front.

  • Thumbnail for Chinese Mutton Fat Jade with Wooden Stand (front)
    Chinese Mutton Fat Jade with Wooden Stand (front)

    3 7/8" l. Greenish-white jade with russet markings carved in an archaistic style standing dragon, handcarved fitted wood stand.

  • Thumbnail for Colorado Mountain Scenery 12 Garden of the Gods
  • Thumbnail for Colorado Mountain Scenery 13 Gateway Rocks, Garden of the Gods
  • Thumbnail for Chinese Carved Gourd with Literary Scenes (2 view 2)
    Chinese Carved Gourd with Literary Scenes (2 view 2)

    1 1/2"h x 1 3/4"l (including base). Side view of finely carved gourd showing scenes from literature and opera.

  • Thumbnail for Chinese Carved Nuts with Literary Scenes (1 view 3)
    Chinese Carved Nuts with Literary Scenes (1 view 3)

    1 1/2" h x 1 3/4" l (including base). Side view of finely carved gourd showing scenes from literature and opera.

  • Thumbnail for Chinese Carved Gourd with Literary Scenes (2 view 3)
    Chinese Carved Gourd with Literary Scenes (2 view 3)

    1 1/2"h x 1 3/4"l (including base). Side view of finely carved gourd showing scenes from literature and opera.

  • Thumbnail for Letter Seal
    Letter Seal by Unknown

    2 (L) x 1/2 (Dia.) inches. Conical iron seal with a rattle inside and a lotus flower finial with a hole in it for a cord. Reticulated and engraved floral design, the vase with calligraphic design.

  • Thumbnail for Gold Lacquer Inro with Ivory Netsuke - front view
    Gold Lacquer Inro with Ivory Netsuke - front view

    H: 6 cm W: 5 cm L: 1.8 cm D: of netsuke 4.2 cm. Gold lacquer inro with overlay design in mother of pearl and shakudo. Design: flying cranes. Ivory netsuke: turtle and toad; signed inside. Cover: Korin

  • Thumbnail for Chinese Carved Gourd with Literary Scenes (2 view 4)
    Chinese Carved Gourd with Literary Scenes (2 view 4)

    1 1/2"h x 1 3/4"l (including base). Side view of finely carved gourd showing scenes from literature and opera. Detail here of inscribed text.