The United States has seen a concerning escalation of opioid overdose death rates in the 21st century. With some states suffering more than others, it is crucial to determine state-level factors that contribute to the reduction of mortalities. Using a fixed-effects regression model, this thesis examines the determinants of opioid overdose death rates in the United States from 2013-2016 across all states and the District of Columbia. The major findings are that medical cannabis laws play a significant role in reducing deaths, while recreational cannabis laws and over-the-counter Naloxone do not. Additionally, the most effective form of PDMP is mandatory reporting of suspicious behavior.