This paper investigates the relationship between income inequality and suicidal behavior in the United States. Empirical results from all 50 states and aggregate U.S. data between 1999 and 2015 provided significant results describing the association between suicide rates and economic factors. Specifically, economic growth, median household income, and income inequality seem to have a significant impact on male suicide rates. Contrary to prior studies, increases in median household income corresponded to higher male suicide rates. Additionally, data suggest gross domestic product (GDP) per capita has a positive relationship with suicidal behavior. However, in support of the held hypothesis, the results show that as the level of income inequality in the United States increases there is a significant decline in male suicide rates. The results demonstrate the importance of researching the socio-economic factors that may be contributing changes in suicide rates.