The fields of immigration and innovation have traditionally been thought of as two distinct areas of study. This paper will serve as a bridge as it examines this relationship through an empirical investigation of the impact of high-skilled immigration on U.S. innovation. A modified national ideas production function is used to estimate the relationship between high-skilled immigrants and patents. A second set of equations is used to isolate patenting activity in the metropolitan regions of the Bay Area, Des Moines, Seattle, and New York. The most significant discovery is that high-skilled immigration has a positive effect on innovation. These results present strong evidence that the United States should liberalize its immigration policies in order to more proactively foster innovation across the country.